GenetureSeq Prep Kit-HRR-HRD Panel
Homologous Recombination Deficiency (HRD) refers to a state of Genomic instability in which cells cannot effectively repair DNA double-strand breaks through the homologous recombination repair (HRR) pathway, resulting in genomic scars. It is one of the most important biomarkers in the field of cancer precision medicine in recent years. Hrd-positive patients are more sensitive to PARPi, and the main mechanism of PARPi is to prevent cancer cells from repairing DNA damage by inhibiting the activity of PARP enzyme, especially for tumor cells with DNA repair defects. The HRD directly determines eligibility for PARP inhibitor (PARPi) and platinum-based chemotherapy.
This kit detects 112 HRR genes +HRD score to evaluate the HRD status of tumor samples of patients. It can also analyze the pathogenicity and heredity of related HRR genes to help identify the cause and provide comprehensive test results support for clinical treatment, prognosis evaluation, and family prevention of patients.
Model：96T
- SKU: 0207022
- Category: Geneture Gene Sequencing Kit
Product Features:
1. Lean: high performance DNA probe with 99%/85% homogeneity/capture efficiency.
2. Comprehensive: 100+HRR genes and HRD scores were detected simultaneously in one experiment.
3. Strong compatibility: Illumina platform and MGI platform are applicable.
4, Fast: support 1-4 hours rapid hybridization, and maintain excellent performance.
5. Accurate results: the SNP loci were optimized for accurate analysis.
6, Flexible: support multiple miscellaneous, improve the utilization rate of reagents.
Storage Condition:
The reagent was composed of three parts, Part1 and Part3 need to be transported at -15 ℃ to -20 ℃ and valid for 12 months at -20±5 ℃. Part2 needs 2~8℃ constant temperature transportation, valid for 12 months at 2~8℃.
Additional Information
Principle:
When DNA is damaged, if it cannot be repaired normally through the HR repair pathway, it is HRD, as shown in Figure 1.
Homologous recombination repair systems are particularly important in cancer biology because cancer is a genomic disease and mutations are required for cancer development. Failure to repair double-stranded DNA will lead to genomic instability, and the accumulation of mutations, chromosomal aberrations, and unregulated cell division will eventually lead to cell apoptosis.
Better responses to platinum and PARP inhibitors have been observed in clinical trials in tumors with HRD than in those without HRD. Using this principle, synthetic lethality caused by PARP inhibitors in combination with HRD by interfering with the ability of cells to repair single-stranded DNA provides an effective and immediately available therapeutic alternative to chemotherapy for patients with HRD.
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