What are biomagnetic beads?
Biomagnetic beads refer to superparamagnetic microspheres with fine particle size, which generally have super paramagnetic properties. It can rapidly gather in the magnetic field, and when it leaves the magnetic field, it can disperse uniformly to help the magnetic separation.
What are the application areas?
By coating the surface of magnetic beads with specific antibodies, receptors, etc., it is used to separate and purify the target in the sample. Magnetic beads have been widely used in immunoassays, nucleic acid separation and extraction, cell sorting, and enzyme immobilization.
Targeted drug delivery
Targeted drug delivery refers to delivering a specified drug to a specific physiological site, organ, tissue or cell according to the purpose, and exerting the drug effect at that site. The drug-loaded magnetic nanoparticles are composed of a magnetic core with magnetic guidance, a shell with affinity and biocompatibility, and a drug wrapped inside the particle or combined with the shell polymer.
Hyperthermia
The magnetic beads with small particle size are injected into the tumor tissue, and the energy is generated under the action of an external magnetic field and uniformly released to the tumor tissue. Due to the insufficient blood supply in the tumor tissue, the heat diffusion in the tumor cells is slow, resulting in a local temperature increase, thereby killing the tumor cells.
Magnetic resonance imaging contrast agent
Magnetic resonance imaging (MRI) technology can perform rapid non-destructive detection of biological internal organs, and has become one of the most effective methods for early diagnosis of tumors. Iron oxide nanoparticles are the most commonly used MRI contrast agents, and dextran-coated iron oxide is biocompatible and can be excreted through the liver after treatment.
Gene carrier
Nanomagnetic beads are used as gene carriers for gene therapy, cell transfection, etc.
Nucleic acid extraction
Magnetic bead method for DNA extraction is the perfect combination of nanotechnology and biotechnology, and has incomparable advantages over traditional DNA extraction methods. Nucleic acid extraction is the basis of the biomedical field, and the magnetic bead method for DNA extraction is of great significance to promote the rapid development of genetic testing and personalized medicine due to its high efficiency and stability.
Cell separation (CD4, CD8)
It can be further used for tumor detection and diagnosis.
Protein and antibody separation (amino magnetic beads, carboxyl magnetic beads, epoxy magnetic beads)
It can be further used for detection and diagnosis of diseases.
Heavy metal detection (thiol magnetic beads)
It can be further used for sewage treatment and so on.
Nuclear magnetic resonance (uncoated magnetic beads) is used for contrast agents, etc.
Immobilization of enzymes
In the food industry, bioactive peptides are often produced by enzymatic hydrolysis. The use of an external magnetic field can not only control the movement mode and direction of the magnetic bead-immobilized enzyme, improve the biocompatibility and immune activity of the immobilized enzyme, but also improve the stability and catalytic efficiency, and help recycling, greatly reducing the cost.
In addition, biological magnetic beads are also used in the separation of biologically active substances, food safety detection and so on.
Features of Biomagnetic Beads
It can realize automation and mass operation. It meets the operational requirements of high-throughput biology and is conducive to rapid and timely response to major disease outbreaks;
The operation is simple and the time is short. The entire extraction process has only four steps, most of which can be completed within 36-60 minutes;
Safe and non-toxic, no toxic reagents are used, and it is in line with modern environmental protection concepts;
The specific combination of magnetic beads and nucleic acid makes the extracted nucleic acid high in purity and concentration.
Ascend Biotechnology Co., Ltd.,is a wholly-owned subsidiary of the Luoyang Geneture Medical Technology CO.,LTD. Uses nano-biomagnetic beads as the core to produce nucleic acid extractors and their matching magnetic bead nucleic acid extraction kits. At present, it has formed a professional nucleic acid automatic purification program covering whole blood, serum, plants, animals and other samples.If you need more information abou the biomagnetic beads,please feel free to contact